Key Glossary Terms Reinke's Edema "Swelling in Reinke's space"; a voice disorder caused by accumulation of gelatinous substance in Reinke's space Reinke's Space (Superficial Lamina Propria) Layer just underneath the surface lining of the vocal fold; composed of cells, special fibers, and other substances (extracellular matrix); has key role in vocal fold vibration "Stripping" A "radical" surgical procedure that removes ("strips") the top layers of the vocal folds resulting in severe vocal fold scarring and abnormal voice. Due to the resultant damage, this procedure is at present rarely used Glossary

Key Information

A "Man's Voice" in Females with Reinke's Edema

One of the most common complaints in female patients with Reinke's Edema is that their voice sounds like a man's voice – especially noticeable when speaking over the telephone. In fact, this complaint is one of the main reasons why more women than men with Reinke's edema seek medical care.

Red Flag

• In rare cases, Reinke's edema can progress to such a severe level that the enlarged vocal folds cause narrowing of the airway, causing breathing difficulties.
• If this scenario does occur, breathing can become noisy (stridor) and can require increased effort, especially during exercise.
• Any breathing difficulty needs immediate medical attention.

Reinke's edema develops slowly.

Reinke's edema is usually identified in patients age 40 and 60 years. However, since Reinke's edema is a gradual, progressive condition, newly diagnosed patients have actually been experiencing the build-up of gelatinous fluid within their vocal folds for many years.

For unknown reasons, most patients diagnosed with Reinke's edema are post-menopausal women. However, since many cases of Reinke's edema are not identitifed, the true incidence of the condition is unknown and could actually be equal for both sexes.

Possible explanation: Low voice in women is more noticeable. The lower-pitched voice common in Reinke's edema patients is more likely noticed by females – simply because a low voice is unusual in females, unlike a male's voice. Physicians believe that women report more cases of Reinke's edema, even if an equal number of men have developed the condition.

Women usually seek surgical intervention: The overwhelming majority of patients who seek surgical intervention for Reinke's edema are women.

Key Information

• Physicians believe that most individuals (male or female) who smoke over a long period probably develop a certain degree of Reinke's edema. This condition may be the cause of "smoker's voice," the raspy, low-pitched voice, which is often recognizable after years of tobacco use.
• Although a review of patient complaints provide important clues towards the identification of Reinke's edema by the voice physician, examination of the voice box is critical in the identification of Reinke's edema.

In general, vocal folds are quite sensitive to any irritation. If irritation persists, voice disorders, like Reinke's edema, will oftentimes result.

Majority of the cases of Reinke's Edema are caused by one or a combination of the risk factors below.

1. Smoking is a major risk factor for Reinke's edema, just as it is the major risk factor for cancer of the lungs, throat, and voice box. However, not all smokers get Reinke's Edema.
2. Voice overuse and "abuse": Constant voice overuse, misuse, or "abuse" can cause irritation to the vocal folds – which may result in several voice disorders, one of which is Reinke's edema.
3. Reflux or backflow of stomach fluids to the voice box (laryngopharyngeal reflux): Stomach fluid is highly acidic. Stomach lining cells have special properties to resist irritation from its acidic fluids. The lining cells of the throat and voice box are not resistant however, therefore exposure to stomach fluid backflow (reflux) causes significant irritation to the voice box resulting in various abnormalities and voice disorders, one of which is Reinke's edema. (For more information, see Reflux Laryngitis.)

Although these three risk factors can cause Reinke's edema, not all individuals with these risk factors develop Reinke's edema.

Physicians are not certain why some people with these risk factors do not develop any voice disorder, or why some develop Reinke's edema while others develop other vocal fold abnormalities such as vocal fold scarring, vocal fold cancer, or vocal fold cysts.

Although the reasons for why only some individuals get Reinke's edema are unknown, factors that worsen risk for Reinke's edema are.